RUNX1 and precursor B-cell acute lymphoblastic leukemia: To investigate whether EB mice recapitulate selected gene expression signatures found in human B-ALL, we correlated the expression of three pro-survival Bcl2 family members (MCL1, BCL2 and BCL2L1 [BCL-XL]) and three key transcription factors (EBF1, TCF3 and RUNX1) in samples from a study of 177 pediatric patients with high-risk B-ALL (Figure 5d).8 B-ALL tumors often exhibit expression of multiple pro-survival Bcl2 family members.