Since miR-137 functions as a global tumor suppressor miRNA in a wide spectrum of human cancers whereas miR-122 is a liver-specific miRNA downregulated in hepatocellular carcinoma,28, 29, 30, 31, 32, 33, 34 we focused on miR-137 regulation of ASCT2 in the current study. This evidence concerns the gene SLC1A5 and hepatocellular carcinoma.