In a previous study, we have identified the differentially expressed mRNAs between WD and FOH feeding animals using RNA-seq, and the results indicated that fish oil protects liver from WD-induced hepatic dyslipidemia and inflammation through altering the expression of a number of genes such as Insig2, Abcg8, Pcsk9, and Per3. The gene discussed is PCSK9; the disease is metabolic syndrome.