Therefore, FISH is becoming a more vital tool to detect and monitor the specific therapy with regards to the gene abnormalities; for example, the detection of the BCR/ALB1 translocation in chronic myeloid leukemia, human epidermal growth factor receptor 2 (HER2) augmentation in breast cancer, and anaplastic lymphoma kinase (ALK) rearrangement in adenocarcinoma [9-10]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.