CD4 and in situ carcinoma: However, as FrIII non-Treg were overrepresented in CIS (Figure 2), the percentage of total Treg (CD4+FoxP3+CXCR5−) cells with a CD161+ Th17-like FrIII phenotype was greater, relative to HC (mean (s.d.)3.74 (1.40) and 2.77 (1.06), P=0.023).