Although one study reported a lower percentage of non-efficient helper Tfh1 cells in MS,15 another reported no difference in Tfh helper subset frequency, in agreement with the results presented here.8 Of note is the fact that, of the two aforementioned studies, only Dhaeze et al.8 employed FoxP3 staining to discriminate between Tfr and Tfh populations. The gene discussed is FOXP3; the disease is myeloid sarcoma.