In addition, diabetes impairs the PI3K/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3-β) signaling pathway and phosphorylation of ERK1/2 (extracellular signal-regulated protein kinases 1 and 2), decreases generation and release of nitric oxide, inactivates ATP-sensitive potassium channels, and elevates oxidative stress98–100. Here, GSK3B is linked to diabetes mellitus.