Moreover, Andersson et al. [67] reported that RyR1 channels in a murine model of limb-girdle muscular dystrophy (LGMD; a deficiency in β-sarcoglycan—a protein involved in the DPG) muscle are oxidised, cysteine nitrosylated, phosphorylated, and depleted of calastabin1 which results in leaky channels along with a decreased fast twitch muscle force and impaired capacity for exercise. Here, RYR1 is linked to limb-girdle muscular dystrophy.