4 Fragoso Fragoso MC MC Domenice Domenice S S Latronico Latronico AC AC Martin Martin RM RM Pereira Pereira MA MA Zerbini Zerbini MC MC Cushing’s syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene Cushing’s syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene J Clin Endocrinol Metab J Clin Endocrinol Metab 2003 2003 5 5 88 88 5 5 2147 2147 51 51 12727968 12727968. The gene discussed is POMC; the disease is Cushing syndrome.