PF2405, a standardized fraction of S. baicalensis, can significantly inhibit TNF-α induced COX-2 expression through JNK1/2 dephosphorylation and p38 MAPK in HT-29 cells and reduced the expression of proinflammatory cytokines and COX-2 in TNBS-induced colitis in female C57BL/6 mice [61]. The gene discussed is TNF; the disease is colitis.