CXCR4 and metastatic neoplasm: Primary tumor expression of CXCR4 (in 57 patients or in 35 patients in a second study), EpCAM (in 90 primary tumor and 16 metastatic tumors), and EZH2 (in 146 patients) were associated with increased distant metastasis and local recurrence during patient follow-up [51, 57–59] indicating that these markers may drive metastasis.