Patients with RA can be treated with (a combination of) non-steroidal anti-inflammatory drugs, corticosteroids, disease-modifying antirheumatic drugs, and/or biological targeted therapies, such as tumor necrosis factor (TNF) inhibitors, B-cell depleting therapy, CTLA4-Ig treatment, and interleukin-6 (IL-6) receptor antibody treatment (8, 9). This evidence concerns the gene TNF and rheumatoid arthritis.