CD8A and obesity due to melanocortin 4 receptor deficiency: Like macrophages, lymphocytes can be divided into populations with primarily proinflammatory functions (including CD8+ cytotoxic T cells, Th1, Th17) or primarily regulatory functions (including Treg or Th2) and the skewing of the adaptive immune milieu toward a proinflammatory phenotype can exacerbate the metabolic disturbances associated to obesity (Nishimura et al., 2009; Winer et al., 2009; Shen et al., 2015).