Activation of PPARγ by TZD leads to increase the storage capacity of fatty acids in the adipocytes and thereby to decrease the amount of circulating fatty acids and ameliorate the insulin resistance (Siersbaek et al., 2010), which finally leads to the reduced plasma insulin and glucose levels (Olefsky, 2000; Leonardini et al., 2009; Sugii et al., 2009). The gene discussed is INS; the disease is Insulin resistance.