CSF1R blockade also showed positive effect in mutant superoxide dismutase 1 (SOD1) models of Amyotrophic Lateral Sclerosis (ALS) by reducing microglial proliferation in the spinal cord and macrophage infiltration into peripheral nerves (Martínez-Muriana et al., 2016). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.