PRNP and Creutzfeldt Jacob disease: A recent study demonstrated subtype-specific and region-specific changes in glia activation and the expression of inflammatory mediators in CJD, with inflammation being pre-dominant in the cerebral cortex in the CJD subtype PRNP codon 129 Met/Met type 1 (MM1) and in the cerebellum in PRNP codon 129 Val/Val type 2 (VV2) cases (Llorens et al., 2014).