miR-433 binds to the promoter region of FGF20. A variant, rs12720208, at the miRNA binding site of FGF20 is associated with PD, as its risk allele prevents miR-433 from attaching and leads to increased FGF20 translation and subsequent α-synuclein expression (Wang et al., 2008). This evidence concerns the gene SNCA and Parkinson disease.