The observation that ARC ACBD7 produced a fragment homologous to the anorexigenic DBI/ACBP-derived peptide ODN prompted us to hypothesize that ACBD7-containing neurons could be involved in energy balance, all the more so that there existed a Acbd7 polymorphism that had been associated to obesity in humans (Comuzzie et al., 2012). This evidence concerns the gene ACBD7 and obesity due to melanocortin 4 receptor deficiency.