The segment for LMBR1 includes three genes (i.e. LMBR1, NOM1, and RNF32) and lies within the 450 kb candidate region identified before [6].Mutations in the ZRS is playing an important role in the pathogenesis of PPD (Additional file 4: Table S3). The gene discussed is NOM1; the disease is progressive pseudorheumatoid arthropathy of childhood.