In conclusion, the present study reports for the first time anassociation between PAI-1 4G/5G polymorphism and risk ofimplantation failures and moderate risk of early and recurrentmiscarriages in PCOS women of South Indian population.Although the 4G/5G are not found to be associated with PCOS risk(p value 0.65), however, it’s been noted that PCOS women carrying4G/5G mutation are prone to early pregnancy loss, includingMissed Abortion (MA), Recurrent Pregnancy Loss (RPL) andSpontaneous Abortion (SAB) and Implantation Failure (IF). The gene discussed is SERPINE1; the disease is polycystic ovary syndrome.