SERPINE1 and polycystic ovary syndrome: It was earlierreported that the PAI-1 activity is positively associated with the riskof first trimester miscarriage in PCOS women, due to its increasedexpression of PAI-1 levels associated with the polymorphism,leading to coagulation or clotting, and significant correlation wasfound in women with polycystic ovary syndrome (PCOS) betweenelevated levels of PAI-1, and early pregnancy loss (EPL) [6].