The aim of the research is to studyand determine the impact of clinical and genetic (PAI-1-675 4G/5Gpolymorphism (rs1799889)) factors on polycystic ovary syndrome(PCOS) of South Indian Population, and to help the scientific andmedical community towards treating the PCOS affected women ina more appropriate and best possible way [9]. The gene discussed is SERPINE1; the disease is polycystic ovary syndrome.