This might be expected, given our results from the colorectal cancer cell line HCT116 whose β-catenin-dependent transcription is attenuated by UBR5 KO (Figures 4D and 4E) and whose proliferation is slowed down by VCP/p97 inhibition (Magnaghi et al., 2013). This evidence concerns the gene UBR5 and colorectal cancer.