Disease-causing sequence variants in RDH12 are identified in up to approximately 10% of LCA/EOSRD patients.9 19RDH12 encodes retinol dehydrogenase 12, a component of the visual cycle, which when deficient is believed to result in retinal toxicity secondary to all-trans-retinal accumulation.86 The gene discussed is RDH12; the disease is severe early-childhood-onset retinal dystrophy.