In contrast to other forms of LCA, RPGRIP1-LCA appears to be relatively non-progressive, following an initial rapid decline in visual function.18 Furthermore, photoreceptors in the central retina appear to remain present for a significant period following deterioration of visual function.70 These features suggest a wide window of opportunity for potential intervention. The gene discussed is RPGRIP1; the disease is Leber congenital amaurosis.