APOE and atherosclerosis: Another difference between the two atherosclerotic models is that ApoE-/- mice subjected to either a chow- or an atherogenic- diet carry most of their cholesterol in the apoB48-containing VLDL particles, whereas Ldlr-/- mice on a chow diet have predominantly apoB100-containing LDL particles, a feature that is more relevant to human pathogenesis of atherosclerosis [54, 93].