Although the studies on p47phox deficiency give an insight into the role of Noxs in atherosclerosis, it is difficult to dissect the particular role of individual Nox homologues to the above findings, since Nox2 interacts mainly with p47phox and Nox1 mainly with Noxo1 but the interaction of Nox1 with p47phox cannot be ruled out [226]. The gene discussed is NCF1; the disease is atherosclerosis.