Further to the increase of Th1 cells, upregulation of T-helper Type 17 (Th17) cells and subsequent expression of interleukin 17 that advocates atherosclerosis are apparent in the aorta and as the duration of a western-type diet advances, Th17 and Th1 cells accrete in splenocytes, suggesting that there is a systemic upregulation of T helper lymphocytes [98, 103]. The gene discussed is IL17A; the disease is atherosclerosis.