As we did not observe differences in TRAF6 expression or mechanistic evidence for deregulated NF-κB activation between patients with different TRAF6 haplotypes, we cannot attribute whether the observed effects on peritoneal inflammation and infection are direct consequences of altered macrophage signaling or are indirectly mediated by immune cells in other compartments, e.g. in gut-associated lymphatic tissue. Here, TRAF6 is linked to infection.