We have previously reported a murine model of NOMID in which NLRP3 was constitutively activated globally as a result of the mating of Nlrp3fl(D301N)/+ mice with mice expressing Cre under the control of the Zona pelucida 3 (ZP) promoter (NLRP3ZP)14. Here, NLRP3 is linked to CINCA syndrome.