NLRP3 and CINCA syndrome: Given that stromal cells/osteoblasts and chondrocytes are the only cells capable of forming the bony outgrowths found in NOMID patients6, 13, we therefore activated NLRP3 in common chondrocyte and osteoblast progenitors using Twist-2/Dermo-1-Cre (DM1) to generate Nlrp3DM1 mice.