Conversely, breast cancer cells overexpressing SFRP1 (MCF7-SFRP1) express less EGR2 when compared with vector transfected cells (MCF7-pCDNA) and exogenous rSFRP1 treatment reduces EGR2 expression in MCF7 cells (Fig. 1b). The gene discussed is SFRP1; the disease is breast carcinoma.