Serum level of IL-4 was significantly increased in NB patients compared with healthy controls (109.9 ± 21.8 vs 682.6 ± 170.2, p < 0.001, Fig. 3c) while there was no significant difference in serum IL-10 between patients with NB and healthy controls (8.1 ± 1.3 vs 11.1 ± 3.0, p = 0.3299, Fig. 3d). This evidence concerns the gene IL4 and neuroblastoma.