As shown in Fig. 4c, the expression of CD23 on B cells were up-regulated in NB patients (MFI: 45.3 ± 3.2 vs 66.0 ± 7.5, p = 0.03) while CD40 and HLA-DR expression was not changed in NB patients (MFI: HLA-DR, 1557.0 ± 89.5 vs 1415.0 ± 197.1, p = 0.48; CD40, 55.6 ± 6.6 vs 45.5 ± 6.0, p = 0.32). Here, CD40 is linked to neuroblastoma.