PLG and dysplasminogenemia: Subsequently, an amino acid substitution of Ala620 to Thr (Plg-A620T, rs121918027, c.1858G>A, Plg-A601T in the mature protein numbering, also known as Plg-Tochigi), close to the active site His622 of the catalytic triad, was identified in patients with dysplasminogenemia [8, 9].