A functional network analysis performed by the CARDIoGRAMplusC4D Consortium (as part of the largest GWAS meta-analysis available at the time of initiation of our study) suggested that SNPs related to the APOA1, IL6R, MRAS, and PLG genes may act on CAD development by affecting pathways of acute phase response signaling [11]. Here, IL6R is linked to coronary artery disorder.