APOE and Alzheimer disease: The marker rs2075650 is located in the TOMM40 gene, just upstream of APOE, and APOC1. The CAD risk allele (G) has been associated with a range of other phenotypes including reduced longevity [24], reduced BMI [25], increased low-density lipoprotein cholesterol (LDL-C) [22,26], and an increased risk of Alzheimer’s disease [27].