Future studies using deep sequencing of the TOMM40/APOE locus in large clinical samples are warranted to determine if rs2075650 is truly causing opposite allelic effects on CAD and hs-CRP, or if the opposite association is explained by underlying linkage disequilibrium with several hidden functional variants of which some affect the development of CAD independent of hs-CRP. Here, APOE is linked to coronary artery disorder.