Therefore, this study is expected to analyze the relation between the indexes, including VD, in perimenopausal women of this region and osteoporosis, and define the risk factors resulting in the occurrence of osteoporosis to perimenopausal women of this region so as to provide clinical guidance for effective prevention and treatment of osteoporosis by investigating the incidence of osteoporosis in perimenopausal women at the age of 40–60 in Xi'an region of Shaanxi province, and the distribution of calcium-phosphorus metabolic indexes including VD, PTH, Ca and P. The gene discussed is PTH; the disease is osteoporosis.