However, in fact this study is not challenging the prevailing academic identity theory, but hopes to put forward that this regional perimenopausal women have a variety of physiological and pathological changes, including lack of VD, osteoporosis and bone hyperplasia, etc. Therefore we can’t assess patient's bone metabolism level simply rely on Ca, P, PTH and VD, the level of bone metabolic markers and different parts of the lumbar spine and femoral neck bone mineral density index should also be analyzed to conclude more rational results. The gene discussed is PTH; the disease is osteoporosis.