IL-5, IFN-γ (interferon gamma) and TH17 (CXCL-1, IL-17A, IL-8) associated cytokines were positively associated with Difficult-to-Control asthma; while EGF (epidermal growth factor), eotaxin, IL-lβ, IL-4, IL-12p40, IL-13, and MDC (macrophage-derived chemokine) were positively associated with Easy-to-Control asthma. This evidence concerns the gene CXCL8 and asthma.