To examine whether myeloid cell-derived TGF-β regulates cross-priming of tumor antigen-specific CD8+ CTL in an autophagy-dependent fashion, TAM were isolated from B16-OVA-tumor-bearing Atg5flox/flox or LysM-Atg5-/- mice, and then used for cross-priming of OVA-specific T cells. This evidence concerns the gene ATG5 and neoplasm.