ATG5 and melanoma: Furthermore, treatment with CSF-1 receptor kinase inhibitor, GW2580, suppressed the lung and liver metastasis of B16 melanomas and liver metastasis of MC38 colon tumors in Atg5flox/flox mice, whereas it had little effect on their metastatic potentials in LysM-Atg5-/- mice (Fig 7D).