To explore the role of the autophagic pathway in myeloid cells in the regulation of effector activities, we co-cultured syngeneic wild-type CD4+ or CD8+ T cells with Atg5flox/flox or LysM-Atg5-/- bone marrow-derived macrophages (BMDM) loaded with dying OVA-expressing EG7 tumor cells and then analyzed the T helper cell differentiation and cytotoxic activities of T cells. This evidence concerns the gene CD4 and neoplasm.