Although we have identified the repeat E of Xist RNA as a binding region of ASH2L, a recent formaldehyde-crosslinked RIP analysis using a human myelogenous leukemia cell line revealed that several chromatin-associated proteins, such as components of PRC2 (SUZ12 and EZH2) and a component of histone deacetylase NuRD complex (CHD4), also bind to repeat E [47–49]. This evidence concerns the gene CHD4 and myeloid leukemia.