XIST and myeloid leukemia: Our data in Figs 3, 4 and S5, however, indicate that the repeat E is dispensable for X-linked non-escape gene silencing and for the recruitment of EZH2 and H3K27me3; thus, Xist repeat E is unlikely to be a major EZH2 binding region observed in a human myelogenous leukemia cell line.