Double mutation of K91, P96 to A91, A96 in either linear or cyclic forms were also shown to be active, with suppression of EAE in SJL/J mice, higher Th2 over Th1 cytokines produced, bound to HLA-DR4, the cyclic forms were more stable to lysosomal enzymes and induced high levels of IL-10 of peripheral blood mononuclear cells from patients with MS [61]. This evidence concerns the gene IL10 and myeloid sarcoma.