MBP and myeloid sarcoma: In addition, we have shown that mannan conjugation of self-MBP, PLP or MOG native peptides or altered peptide ligands, are able to divert Th1 responses to Th2 responses in human PBMC from MS patients, in immunized mouse spleen cells and are able to ameliorate EAE in mice [59,60,61,62,63,64,65,66,67,68,69,70,71,72,73].