Interestingly, over 50 antibodies isolated from cerebrospinal fluid from patients with MS did not react to MBP, PLP or MOG [86] but some groups reporting that they bind to intracellular proteins such as, MKNK1/2, FAM84A, AKAP12A and glial potassium channel KIR4.1, or, against intracellular lipid determinants [87,88]. This evidence concerns the gene MOG and myeloid sarcoma.