Classical CD8 T cells or cytotoxic T cells (Tc1 cells), recognize short antigenic 7-9-mer peptide epitopes presented on the surface of APC in complex with MHC class I. In MS there is a genetic association with HLA-A3 [82]; HLA-A2 has been shown to reduce the risk of MS in individuals that also express MHC class II, HLA-DRB1*1501. The gene discussed is CD8A; the disease is myeloid sarcoma.