For example, ICAM-1 induces leukocyte adhesion to endothelial cells, and up-regulation of inflammatory mediators causing endothelium dysfunction and administration of an ICAM-1 antibody, genetic knockout of ICAM-1, or prevention of neutrophil infiltration in mice attenuates renal ischemia-induced AKI [112]. The gene discussed is ICAM1; the disease is acute kidney injury.