PPARG and type 2 diabetes mellitus: As such, it has been shown that peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists as used in the treatment of T2DM and stimulating lipid uptake and glucose metabolism may simultaneously improve glucose tolerance, decrease oxidative stress and alleviate telomere attrition in myocardial cells from diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats [71].