This RCT demonstrated a statistical and clinically significant improvement for a lifestyle intervention following the addition of a novel herbal combination compared with lifestyle intervention alone with reducing PCOS symptomology including a reduction in the number of days of the menstrual cycle (a large treatment effect on oligomenorrhoea/amenorrhoea), improved anthropometry, oestradiol and LH, fasting insulin, blood pressure, conception rates and quality of life. The gene discussed is PLOD1; the disease is amenorrhea.