In that RCT, 35 obese women (BMI ≥27) with PCOS taking metformin demonstrated a mean reduction in the number of days in the menstrual cycle from 98 to 74 days (25%, p < 0.05) with significant improvements in waist‐to‐hip ratio and fasting insulin (Morin‐Papunen et al., 2000). The gene discussed is INS; the disease is polycystic ovary syndrome.