As assessed by IHC, PRODH1 and P4HA3 (the enzymatic subunit of P4H involved in proline hydroxylation in collagen synthesis) were found in tumour gland-like structures and we confirmed epithelial localization by co-staining with wide-spectrum cytokeratin (wsKRT) in murine tumour sections (Fig. 2b,c). This evidence concerns the gene P4HA3 and neoplasm.