The tau radioligand should have a very high specificity for tau because it is often co-localized with other proteins that have β-sheet secondary structures.33, 34 Due to the involvement of pathological tau in glial cells, the radioligand should also have very low nonspecific binding in white matter.34 As mentioned, tau has numerous isoforms and may aggregate in different conformations and therefore, it may be very challenging for one tau radiotracer to successfully image all tauopathies. Here, MAPT is linked to tauopathy.