MAPT and tauopathy: However, in the PSP cases there was a signal in the entorhinal cortex, suggesting that [18F]AV-1451 was labeling age-related tau accumulation according the Braak staging theory.39, 53 It was concluded from this preclinical study that [18F]AV-1451 bound with selectivity to PHF-tau in AD and age-related tau accumulation, but did not bind to any significant degree to straight filaments of tau that are present in non-AD tauopathies (PiD, PSP, and CBD), and aggregates containing β-amyloid and α-synuclein.