MAPT and supranuclear palsy, progressive, 1: There was significant retention of [18F]THK-5351in the globus pallidus and the midbrain of PSP patients.51 Additional autoradiography on separate PSP brain slices revealed that [3H]THK-5351 signal in the midbrain was highly correlated with IHC staining of tau aggregates.51 Continued investigation into the efficacy of [18F]THK-5351 imaging in PSP and other Parkinsonian tauopathies should involve increased sample size and correlations between ante-mortem and post-mortem data.