This is thought to be due an age-related accumulation of PHF tau.56 Another human study was performed with AD patients (44), MCI patients (87) and healthy older adults (42) to test whether [18F]AV-1451 binding reflected the Braak histopathological staging.39, 57 The older control group was defined as individuals ≥50 years old. Here, MAPT is linked to Alzheimer disease.