MAPT and Alzheimer disease: Additional binding to neuromelanin-containing cells, such as those in the substantia nigra pars compacta was observed.53 Another post-mortem examination of [18F]-AV-1451 in AD (n = 5), PSP (n = 6), PiD (n = 5), and CBD (n = 4) was performed by Sander and colleagues (2016).54 [18F]AV-1451 signal was consistent with IHC staining of tau in AD and PiD slices.