TARDBP and Alzheimer disease: However, there was no substantial signal in PSP and CBD brain slices, consistent with the previous post-mortem study.54 Lowe and colleagues (2016) tested AV-1451 binding in 38 cases, including age-related tauopathies, AD, PiD, CBD, PSP, FTDP-17, frontotemporal lobar degeneration with TDP-43 immunoreactive lesions (FTLD-TDP), lewy body disease (LBD), and multiple system atrophy (MSA).55 Cases with age-related tauopathies and AD cases demonstrated binding of AV-1451 to areas of high PHF concentration.