MAPT and Alzheimer disease: There were significantly different binding patterns of [18F]THK-5105 and [18F]THK-5117 compared to [11C]PIB, suggesting that the arylquinone derivatives do not exhibit Aβ plaque binding.45 In a clinical study [18F]THK-5117 retention differed from that of [11C]PIB and the [18F]THK-5117 SUVRs of the temporal cortex were significantly higher in AD patients compared to healthy controls.46 High pathological tau load in the temporal cortex is associated with cognitive decline.