As the association between IR and NAFLD is well-established in the literature, it is reasonable to assume that there is some connection between VDD and liver disease, as reported in the experimental study developed by Roth et al. (2012) [26] in which VDD caused IR due to an increase in the gene expression of liver resistin, inflammatory liver regulation, and genes of oxidative stress. The gene discussed is RETN; the disease is metabolic dysfunction-associated steatotic liver disease.