PPARGC1A and type 2 diabetes mellitus: Several metabolic endpoints in the high-cholesterol diet-fed mice have been noted that may underpin the behavioural changes, and these include increased insulin resistance, which is associated with a reduction in the expression of peroxisome proliferator-activated receptor gamma coactivator 1a (PPARGC1a), a marker of mitochondrial disbalance and impaired mitochondrial activity in dietary-induced type 2 diabetes [16, 24–26].