From the three down-regulated genes (ST3GAL6, C12orf39, and CA3), ST3GAL6 is particularly interesting since a recent paper shows that the altered N-glycosylation of TNF-alpha treated adipocytes correlate with regulation of specific glycosyltransferases, such as the downregulation of ST3GAL6 sialyltransferase.25 Therefore, adipose inflammation associated with obesity modulates protein glycosylation, leading to an important biological deregulation.25 This kind of deregulation could lead to a broad effect on the biology of the cells. The gene discussed is ST3GAL6; the disease is obesity due to melanocortin 4 receptor deficiency.