By connecting genes to pathways, we find a set of 16 pathways (Supplementary Table 3) that can be grouped into three main categories: adhesion molecules which are involved in the interaction with the extracellular matrix and related intracellular signals (i.e., PI3K-AkT pathway); inflammation that can be involved in tumor development; and pathways connected to typical symptoms of obesity, from salivary secretion to digestive problems. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.