Other target genes encode proteins such as MADCAM1 (mucosal vascular addressin cell adhesion molecule 1), MARCKSL1 (macrophage myristoylated alanine-rich C kinase substrate-like 1), and CDH4 (cadherin 4), which are associated with cell adhesion and migration, a process known to be regulated by MNRR1 [29] and LACTB (lactamase beta), which forms filaments in the mitochondrial IMS and is part of a network of genes that were validated to have a casual association with obesity traits [85]. The gene discussed is MADCAM1; the disease is obesity due to melanocortin 4 receptor deficiency.