HNF1B and hepatocellular carcinoma: As shown in Fig. 4E,F and Supplemental Fig. E,F, the expression of HPC markers in the DAPT group and shRNA group was significantly lower than that in the HNF-1β overexpressed HCC cells, which suggested that Notch signalling is important downstream of HNF-1β for the expression of biliary/HPC markers.