In colorectal cancer, SIOMICS predicted five shared motifs, which were similar to the motif of the TFs SP1, the CAC-binding protein, TFAP2A (AP-2), KLF6 (GBF), and EGR1 (KROX), respectively (the names in parentheses are the corresponding TRANSFAC TF names). The gene discussed is KLF6; the disease is colorectal cancer.