To further understand signal pathways involving Znf179 during gliomagenesis, we also analyzed the expressions of glioma pathological molecular factors, including p53 (a ARF-MDM2-p53-related factor), EGFR and Foxo3 (RTK-PI-3K-related factors), and cdk4 (a INK4a-Rb-related factor) in primary GBM cells stably expressing Flag-Znf179. This evidence concerns the gene RNF112 and central nervous system cancer.