In the CGAP database analysis and IHC results, gene and protein expression levels of Znf179 were much lower in glioma tissues compared to normal brain tissues, suggesting that Znf179 may play a role as a suppressor to repress the transformation, viability, and malignant progression of gliomas, which promoted us to study the effect of Znf179 on gliomas. The gene discussed is RNF112; the disease is central nervous system cancer.