Considering only the 3 top scoring potential regulators, we found (Fig. 2A) that the udder response towards the E. coli infection was guided by the effects elicited through the bacterial cell wall component LPS (lipopolysaccharide) and the well-known master cytokines TNF (tumor necrosis factor α) and IL1B (interleukin 1B). The gene discussed is IL1B; the disease is escherichia coli infection.