CYP4Z1 and breast carcinoma: Overexpression of CYP4Z1 is associated with increased production of 20-hydroxyeicosatetraenoic acid (20-HETE) in BRCA, and it has been hypothesized that CYP4Z1 metabolizes arachidonic acid to 20-HETE, resulting in enhanced growth and spread of breast cancer cells29, 30.