FXN and Friedreich ataxia: The function of Tsf3 has not been characterized yet, and its identification as a suppressor for FRDA phenotypes in flies provides indirect evidence of its involvement in iron metabolism in Drosophila. Similarly, genetic suppression of the mitochondrial iron importer mitoferrin [19] was able to counteract physiological and molecular phenotypes of frataxin loss-of-function in flies [27].