The glucokinase regulatory protein gene (GCKR; MIM 613463) encodes for glucokinase regulatory protein (GKRP; NP_001477), the main allosteric inhibitor of glucokinase (HK4; P35557.1; GCK hereafter), and is a T2D-associated locus. The gene discussed is GCK; the disease is type 2 diabetes mellitus.