Five of the genes affected by a single technology indel (WGS) in the MSI tumor (GNAS, HOXC13, MAPK1, and ZFHX3) and two of the genes affected by a single technology indel (WGS) in the MSS tumor (GNAS and HOXD13) were also listed in the cancer gene census list of the COSMIC database. The gene discussed is GNAS; the disease is neoplasm.