PDE4D and neoplasm: Somatic copy-number alterations (SCNA) found in GC included amplification of EPHB3, and GATA4. Significantly deleted focal SCNAs in GC were, amongst others, in PDE4D and PARK2. The mentioned genes were also affected by somatic alterations in the investigated MSI tumor sample: EPHB3 (somatic nonframeshift deletion), GATA4 (somatic nonframeshift deletion), PDE4D (somatic interchromosomal translocation, large deletion), and PARK2 (somatic large deletion).