OPG was significantly increased in CKD patients as compared to controls, being 2789.54 ± 2432.25 pg/mL in the CKD and 1216.18 ± 443.93 pg/mL in the CNT group (Satterthwaite t-test of means for unequal variances = 4.61, d.f. = 47.169; p < 0.001), for further details see the Additional file 1. The gene discussed is TNFRSF11B; the disease is chronic kidney disease.