This is consistent with the report that plasma OPG concentration predicts the deterioration of kidney function in type 1 diabetic patients [25], and suggests that OPG could be used as a risk marker for CKD not only in type 1 diabetes, but also in patients with hypertension, as it was shown in elderly women [27] and renal transplant recipients [35]. Here, TNFRSF11B is linked to hypertensive disorder.